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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1489215Generated: October 25, 2026

Formaldehyde → 4-[Ethyl-[(4-methoxyphenyl)methyl]amino]but-2-yn-1-ol

https://huagongshe.com/reaction/1489215

Reaction equation

Participants

RoleNameHCIDCharge
ReactantFormaldehydeHCID 712—
ReactantPropargyl alcoholHCID 7859—
ReactantBenzenemethanamine, N-ethyl-4-methoxy-HCID 296018—
Product4-[Ethyl-[(4-methoxyphenyl)methyl]amino]but-2-yn-1-olHCID 4248190—

Reaction Steps

reacting N-ethyl-4-methoxybenzenemethanamine with 2-propyn-1-ol and paraformaldehyde in an inert solvent in the presence of cuprous chloride to produce 4-[N-ethyl-(4-methoxyphenyl)methylamino]-2-butyn-1-ol (V);

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05677346
Source datasetuspto-grants-1997_10
ORD IDord-58868956c6414c31826899fc3216bb7e
Source noteuspto-grants-1997_10