HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → N-Desethyloxybutynin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 1-Chloroethyl chloroformate | HCID 521305 | — |
| Reactant | 4-[Ethyl-[(4-methoxyphenyl)methyl]amino]but-2-ynyl 2-cyclohexyl-2-hydroxy-2-phenylacetate | HCID 5044225 | — |
| Solvent | 1,1-Dichloroethane | HCID 6365 | — |
| Product | N-Desethyloxybutynin | HCID 133577 | — |
Reaction Steps
reacting said 4-[N-ethyl-(4-methoxyphenyl)methylamino]-2-butynyl α-cyclohexyl-α-hydroxybenzeneacetate sequentially with α-chloroethyl carbonochloridate in dichloroethane, followed by methanol to produce 4-(ethylamino)-2-butynyl α-cyclohexyl-α-hydroxybenzeneacetate (desethyloxybutyin).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05677346 |
| Source dataset | uspto-grants-1997_10 |
| ORD ID | ord-08a020ff58324287ba2074fca30cda7b |
| Source note | uspto-grants-1997_10 |