Dimethylamine → HCID 54218653, compound

HRID 1489226Notes

Reaction equation

HRID 1489226 reaction equation
[CH3:1][O:2][N:3]=[C:4]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[O:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:5](OC)=[O:6].[CH3:23][NH:24][CH3:25]>CO>[CH3:23][N:24]([CH3:25])[C:5](=[O:6])[C:4](=[N:3][O:2][CH3:1])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[O:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 53983242HCID 53983242, compound

Product 1

HCID 54218653HCID 54218653, compoundYield 66%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 4.9 g (16.4 mmol) of methyl 2-methoxyimino-2-(2-benzyloxyphenyl)acetate and 0.9 g (20 mmol) of dimethylamine in 20 ml of methanol was stirred at about -25° C. for 60 hours. After removal of the solvent, the crude product was purified by chromatography on silica gel (methyl tert-butyl ether/n-hexane mixture as eluent). Yield: 66%;

Workup

  1. customAfter removal of the solvent
  2. customthe crude product was purified by chromatography on silica gel (methyl tert-butyl ether/n-hexane mixture as eluent)

Sources & evidence

ORD record
ord-a22cffeab38246b084e9098b8f76b312
Source dataset
uspto-grants-1997_10
Patent number
US05677347

Reaction notes

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