反应详情

In 25 ml of acetic anhydride was dissolved 2.8 g of 3-(4-phenylthiazol-2-yl)pyridine-N-oxide. The solution was refluxed for 6 hours with heating. The solvent was removed by distillation. The residue was treated with ammonia water and extracted with dichloromethane. The extract was water-washed, dried and subjected to solvent removal by distillation. The residue was mixed with a small amount of dichloromethane. The resulting crystals were collected by filtration and recrystallized from methanol to obtain 60 mg of 2-(2-oxopyridin-3-yl)4-phenylthiazole as light brown plate crystals.

1. temperatureThe solution was refluxed for 6 hours
2. temperaturewith heating
3. customThe solvent was removed by distillation
4. additionThe residue was treated with ammonia water
5. extractionextracted with dichloromethane
6. washwashed
7. customdried
8. customsubjected to solvent removal by distillation
9. additionThe residue was mixed with a small amount of dichloromethane
10. filtrationThe resulting crystals were collected by filtration
11. customrecrystallized from methanol