HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dicyclohexylcarbodiimide → 5-(N-(9-flourenylmethoxycarbonyl)homophenylalanylamino)-1,3,4-thiadiazole-2-thione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Fmoc-phenylalanine | HCID 978331 | — |
| Reactant | 2-Amino-5-mercapto-1,3,4-thiadiazole | HCID 2723847 | — |
| Product | 5-(N-(9-flourenylmethoxycarbonyl)homophenylalanylamino)-1,3,4-thiadiazole-2-thione | HCID 22878133 | — |
Reaction Steps
Fmoc-phenylalanine (0.8 grams), 1-hydroxybenzotriazole (0.38 grams), dicyclohexylcarbodiimide (0.4 grams) and 5-amino-1,3,4-thiadiazole-2-thione (0.4 grams) were reacted according to the procedure described in Example 1. The resulting product was recrystallized from ethanol/pentane to give a white powder. M.P. 186°-187° C. NMR spectrum (d6 -DMSO) 14.08 (s, 1H), 12.6 (s, 1H), 8.00-7.1 (m, 14 H, NH+aromatics), 4.4-4.1 (m, 4H), 2.8-2.3 (m, 2H), 2.1-1.8 (m, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05677282 |
| Source dataset | uspto-grants-1997_10 |
| ORD ID | ord-d874704f291e44af85becda0eaf8e916 |
| Source note | uspto-grants-1997_10 |