Dicyclohexylcarbodiimide → 5-(N-(4-(4-t-Butylphenylsulfonylamino)benzoyl)-phenylalanyl-valylamino)-1,3,4-thiadiazole-2-thione

Beteiligte Stoffe

Reaktionsschritte

(4-(4-t-Butylphenylsulfonylamino)benzoyl)-phenylalanine-valine, (0.48 grams) 1-hydroxybenzotriazole (0.15 grams), dicyclohexylcarbodiimide (0.17 grams) and 5-amino-1,3,4-thiadiazole-2-thione (0.5 grams) were reacted according to the procedure described in Example 1. The resulting product was recrystallized from ethanol/pentane to give a white solid. M.P. 140°-144° C. NMR spectrum (d6 -DMSO) 14.1 (s, 1H), 12.6,12.5 (s,s, 1H), 10.8 (s, 1H), 8.6-8.2, 7.8-7.4, 7.4-7.0 (m, 15 H, NM+aromatics), 4.8 (m, 1H), 4.35 (m, 1H), 3.5-2.8 (m, 2H), 2.05 (m, 1H), 1.2 (s, 9H), 0.85 (bs, 6H).

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