Thionyl Chloride → HCID 21709149, compound

HRID 1489355Notes

Reaction equation

HRID 1489355 reaction equation
[C:1]1([C:7]2[N:12]=[C:11]([CH2:13]O)[CH:10]=[CH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(Cl)([Cl:17])=O>>[C:1]1([C:7]2[N:12]=[C:11]([CH2:13][Cl:17])[CH:10]=[CH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 21709156HCID 21709156, compound

Product 1

HCID 21709149HCID 21709149, compound

Procedure

A solution of 55 mg 2-phenyl-4-hydroxymethylpyrimidine in 1 mL of thionyl chloride was heated at reflux temperature for 1 hr and the excess thionyl chloride removed by evaporation under reduced pressure to yield 50 mg of 2-phenyl-4-chloromethylpyrimidine as an oil which was used in the next step without further purification or characterization.

Workup

  1. temperatureat reflux temperature for 1 hr
  2. customthe excess thionyl chloride removed by evaporation under reduced pressure

Sources & evidence

ORD record
ord-79754b0e296342bb84d9b3b19844e924
Source dataset
uspto-grants-1997_10
Patent number
US05677454

Reaction notes

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