Sodium Methoxide → HCID 54281780, compound

HRID 1489358Notes

Reaction equation

HRID 1489358 reaction equation
C[O-].[Na+].C([O:7][C@@H:8]1[C@@H:12]([CH:13]=[CH:14][C:15]([O:17][CH3:18])=[O:16])[O:11][C@@H:10]([N:19]2[CH:27]=[C:25]([CH3:26])[C:23](=[O:24])[NH:22][C:20]2=[O:21])[CH2:9]1)(=O)C>CO>[C:15]([CH:14]=[CH:13][C@H:12]1[O:11][C@@H:10]([N:19]2[CH:27]=[C:25]([CH3:26])[C:23](=[O:24])[NH:22][C:20]2=[O:21])[CH2:9][C@@H:8]1[OH:7])([O:17][CH3:18])=[O:16]

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 54037330HCID 54037330, compound

Product 1

HCID 54281780HCID 54281780, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

About 10 drops of a 25% sodium methoxide in methanol were added to a stirred solution of 1.5 g of 3'-O-acetyl-5'-carbomethoxymethylene-5'-deoxythymidine in 150 ml of dry methanol (passed through a bed of neutral alumina). The mixture was stirred at room temperature under a nitrogen atmosphere for an additional 6 hours.

Sources & evidence

ORD record
ord-e1d55d3d7b5a4b8198a14fa4ba8e3356
Source dataset
uspto-grants-1997_10
Patent number
US05677439

Reaction notes

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