Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) → HCID 10154224, compound

Participants

Reaction Conditions

Reaction Steps

(2S)-2'-Fluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone (25 g) was dissolved in 200 ml of ethanol, to which 1.28 g of pyridinium p-toluenesulfonate was added. The mixture was stirred at 55° C. for 2.5 hours and then concentrated. The residue was purified by silica gel chromatography (eluent; hexane:ethyl acetate=9:1 to 5:1) to give 16.4 g of (2S)-2'-fluoro-2-hydroxypropiophenone as a colorless oil.

Provenance & Evidence