Triethylamine → HCID 10578947, compound

Participants

Reaction Conditions

Reaction Steps

2-[(1R,2S)-2-(2,4-Difluorophenyl)-2,3-dihydroxy-1-methylpropyl]-4-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]-3(2H,4H)-1,2,4-triazolone (8.26 g) was dissolved in 100 ml of ethyl acetate, to which 2.89 g of methanesulfonyl chloride and 2.54 g of triethylamine were added dropwise with ice cooling. After stirring at 0° C. for 30 minutes, the solution was washed with water (20 ml×2) and 20 ml of an aqueous solution of sodium chloride successively. The organic layer was dried over magnesium sulfate. The solvent was distilled off under reduced pressure to give 10 g of 2-[(1R,2S)-2-(2,4-difluorophenyl)-2-hydroxy-3-methanesulfonyloxy-1-methylpropyl]-4-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]-3(2H,4H)-1,2,4-triazolone as a colorless oil.

Provenance & Evidence