5'-O-tert-Butyldiphenylsilyl-thymidine → 3'-Deoxy-3'-allyl-5'-O-tert-butyldiphenylsilylthymidine

Participants

Reaction Steps

Utilizing the procedures of Examples 16 and 17 wherein compound 18 was obtained from compound 3 via compound 17, compound 2 is used as the starting material in place of compound 3. Compound 2 is converted via the procedure of Example 16 to an intermediate compound similar to compound 17 except this intermediate differs from compound 17 in that it does not have a blocking group on its heterocyclic base. The intermediate is then treated as per the procedure of Example 17 to give the title compound in 58% yield.

Provenance & Evidence