Triphenylphosphine → HCID 178443930, compound

Participants

Reaction Steps

2.6 ml (16 mmol) of diethyl azodicarboxylate are added dropwise at room temperature to a mixture of 5 g (15 mmol) of 4-[trans-4-(trans-4-propylcyclohexyl)cyclohexyl]-2,6-difluorophenol, 2.1 g (16 mmol) of (S)-(+)-2-octanol, 4.3 g of triphenylphosphine and 80 ml of THF. The mixture is stirred for 2 hours and subjected to customary work-up. Chromatography gives (R)-(-)-4-[trans-4-(trans-4-propylcyclohexyl)cyclohexyl]-1-(1-methylheptyloxy)-2,6-difluorobenzene, C 29 SB 42 Ch 73.8 I, HTP=-7.7, [α]D20 =-6.9 (CH2Cl2).

Provenance & Evidence