Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Formaldehyde | HCID 712 | — |
| Edukt | 1,1,1,3,3,3-Hexafluoro-2-propanol | HCID 13529 | — |
| Edukt | Hydrofluoric Acid | HCID 14917 | — |
| Lösungsmittel | Sulfuric Acid | HCID 1118 | — |
| Produkt | Sevoflurane | HCID 5206 | 87,5% |
Reaktionsschritte
A 500 ml reactor was charged with 50 ml of 98% sulfuric acid, 100 g (5 mol) of hydrogen fluoride, and 30 g (1 mol) of paraformaldehyde. This reaction mixture was heated to 65° C. Then, 134 g (0.8 mol) of HFIP was added dropwise, over 2 hr. Vapors generated by the reaction were collected using water. With this, 140 g of crude SEVOFLURANE was obtained.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US05679576 |
|---|
| Quelldatensatz | uspto-grants-1997_10 |
|---|
| ORD ID | ord-c5ed7c93ae5f4696a4833a8f7e611625 |
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| Quellennotiz | uspto-grants-1997_10 |
|---|
