Ammonia → HCID 22901846, compound

HRID 1489505Notes

Reaction equation

HRID 1489505 reaction equation
[NH3:1].[O:2]=[C:3]1[N:7]([CH2:8][C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])=O)[N:6]=C(C(F)(F)F)O1>C(#N)C>[NH2:6][N:7]1[CH:8]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[NH:1][C:3]1=[O:2]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 22901841HCID 22901841, compound

Product 1

HCID 22901846HCID 22901846, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

75 ml of aqueous ammonia solution (25%) are added to a solution of 25.6 g of 2,3-dihydro-2-oxo-3-tert-butylcarbonylmethyl-5-trifluoromethyl-1,3,4-oxadiazole in 100 ml of acetonitrile. After the slightly exothermal reaction has subsided, the reaction mixture is stirred for 2 hours at room temperature and then for 14 hours at 80° and then evaporated, the residue is treated with trichloromethane, and the trichloromethane mixture is freed from the undissolved components, dried and evaporated. The residue is triturated with diethyl ether and subjected to filtration with suction. This gives the tide compound in the form of pale yellow crystals which melt at 197-200°.

Workup

  1. customAfter the slightly exothermal reaction
  2. waitfor 14 hours at 80°
  3. customevaporated
  4. additionthe residue is treated with trichloromethane
  5. customdried
  6. customevaporated
  7. customThe residue is triturated with diethyl ether
  8. filtrationsubjected to filtration with suction
  9. customThis gives the tide compound in the form of pale yellow crystals which
  10. custommelt at 197-200°

Sources & evidence

ORD record
ord-db5ab8838ec64cbbbff27bb96b0b7658
Source dataset
uspto-grants-1997_10
Patent number
US05679623

Reaction notes

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