5,6-Dichloro-3-oxoindan-1-carbonyl chloride → HCID 67705815, compound

Participants

Reaction Steps

A similar reaction to that of Example 1 was carried out by using 1.0 g of (3R)-3-(1-pyrrolidinyl)methylthiomorpholine, 2.0 ml of triethylamine and 3.0 g of 3-oxo-5,6-dichloro-1-indanecarboxylic acid chloride and the crude product was purified by column chromatography through silica gel using a 100:1 mixture of ethyl acetate and triethylamine as a mobile phase to give 0.82 g of the free basic form of the title compound from the less polar fractions. The product was treated with hydrogen chloride in a similar manner to the latter part of Example 1 to give 0.85 g of the title compound. m.p.: 257°-261° C. [α]D25 +26.8° (c=2.0, methanol)

Provenance & Evidence