Methanol → HCID 56987689, compound

HRID 1489549Notes

Reaction equation

HRID 1489549 reaction equation
COC([NH:5][C@:6]12[CH2:14][N:13](C(OC)=O)[CH2:12][C@H:11]1[CH:10]=[CH:9][CH:8]=[CH:7]2)=O.CO>O>[CH2:12]1[C@@H:11]2[C@@:6]([NH2:5])([CH:7]=[CH:8][CH:9]=[CH:10]2)[CH2:14][NH:13]1

Participants

4

Reactant 2

HCID 887MethanolHCID 86751425HCID 86751425, compound

Product 1

HCID 56987689HCID 56987689, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

Analogously to Step F, 11 g of crude methyl (1S,6R)-1-methoxycarbonylamino-8-azabicyclo[4.3.0]nona-2,4-diene-8-carboxylate are hydrolysed in 150 ml of water using 42 g of Ba(OH)2.8 H2O and worked up accordingly. Yield: 3 g (44.6% of theory based on Step G), boiling point: 70° C./0.1 mbar, [α]D =+235.9° (c=1,14, methanol).

Sources & evidence

ORD record
ord-a0d0657b377240ba8a8894ab8380b8a9
Source dataset
uspto-grants-1997_10
Patent number
US05679689

Reaction notes

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