Methyl 3a-amino-1,3,3a,7a-tetrahydro-2H-isoindole-2-carboxylate → HCID 22902199, compound

HRID 1489550Notes

Reaction equation

HRID 1489550 reaction equation
[NH2:1][C:2]12[CH2:10][N:9](C(OC)=O)[CH2:8][CH:7]1[CH:6]=[CH:5][CH:4]=[CH:3]2>O>[CH2:8]1[CH:7]2[C:2]([NH2:1])([CH:3]=[CH:4][CH:5]=[CH:6]2)[CH2:10][NH:9]1

Participants

3

Reactant 1

HCID 22902217Methyl 3a-amino-1,3,3a,7a-tetrahydro-2H-isoindole-2-carboxylate

Product 1

HCID 22902199HCID 22902199, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Analogously to Step F, 1.4 g (7.2 mmol) of methyl 1-amino-8-azabicyclo[4.3.0]nona-2,4-diene-8-carboxylate are hydrolysed using 4 g of Ba(OH)2.8H2O in 20 ml of water and worked up accordingly. Yield: 0.6 g (61% of theory), boiling point: 65° C./0.1 mbar.

Sources & evidence

ORD record
ord-c591c70a87c442868b7d0095b2069e17
Source dataset
uspto-grants-1997_10
Patent number
US05679689

Reaction notes

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