HCID 22902037, compound → HCID 22902055, compound

HRID 1489560Notes

Reaction equation

HRID 1489560 reaction equation
[N:1]([CH:4]1[CH2:10][CH2:9][C:8]2[CH:11]=[CH:12][C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[CH:14][C:7]=2[N:6]([CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23])[C:5]1=[O:27])=[N+]=[N-]>[C].[Pd].C(O)C>[NH2:1][CH:4]1[CH2:10][CH2:9][C:8]2[CH:11]=[CH:12][C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[CH:14][C:7]=2[N:6]([CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23])[C:5]1=[O:27]

Participants

4

Reactant 1

HCID 22902037HCID 22902037, compound

Product 1

HCID 22902055HCID 22902055, compoundYield 100.3%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

A mixture comprising 0.785 g (2.15 mmol) of 3-azido-1-ethoxycarbonylmethyl-8-phenyl-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-one obtained in the Synthesis Example A-7, 0.05 g of 10% palladium-carbon and 20 ml of ethanol was catalytically hydrogenated at room temperature under 4 atm for 1 hour. After filtering off the catalyst, the filtrate was concentrated. Thus, 0.73 g of the title compound was obtained as a pale yellow oily product. Yield 100%.

Workup

  1. filtrationAfter filtering off the catalyst
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-c32484c1e5ef400ebc45508f0c875f89
Source dataset
uspto-grants-1997_10
Patent number
US05679671

Reaction notes

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