Pentanoic acid, 2-(acetylthio)-3-methyl-, (2S,3S)- → 3-[(2S, 3S)-2-Acetylthio-3-methylvalerylamino]-1-ethoxycarbonylmethyl-1H-[1]benzazepin-2-one
Reaction equation
[NH2:1][CH:2]1[CH:8]=[CH:7][C:6]2[CH:9]=[CH:10][CH:11]=[CH:12][C:5]=2[N:4]([CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:3]1=[O:19].[C:20]([S:23][C@@H:24]([C@@H:28]([CH3:31])[CH2:29][CH3:30])[C:25](O)=[O:26])(=[O:22])[CH3:21]>>[C:20]([S:23][C@@H:24]([C@@H:28]([CH3:31])[CH2:29][CH3:30])[C:25]([NH:1][CH:2]1[CH:8]=[CH:7][C:6]2[CH:9]=[CH:10][CH:11]=[CH:12][C:5]=2[N:4]([CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:3]1=[O:19])=[O:26])(=[O:22])[CH3:21]Participants
3
Procedure
0.525 g (2 mmol) of 3-amino-1-ethoxycarbonylmethyl-1H-[1]benzazepin-2-one and 0.418 g (2.2 mmol) of (2S,3S)-2-acetylthio-3-methylvaleric acid were reacted in the same manner as that of Example A-2. Thus, 0.42 g of the title compound was obtained as a colorless amorphous product. Yield 48%.
Sources & evidence
- ORD record
- ord-b26f59ac4e784c00b4b9b421a449d5e0
- Source dataset
- uspto-grants-1997_10
- Patent number
- US05679671
Reaction notes
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