(S)-3-Amino-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic Acid Ethyl Ester → (3S)-[[(2S,3S)-2-Acetylthio-3,4-dimethyl-1-oxopentyl]amino]-1-ethoxycarbonylmethyl-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-one

Participants

Reaction Steps

0.500 g (1.91 mmol) of (3S)-amino-1-ethoxycarbonylmethyl-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-one and 0.430 g (2.1 mmol) of (2S,3S)-2-acetylthio-3,4-dimethylpentanoic acid were treated by the same method as that of Example 101(h). Thus, 0.420 g of the title compound was obtained.

Provenance & Evidence