Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Hydroxide → 7-Amino-4-(3-bromoanilino)-6-nitroquinazoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 7-Acetamido-4-(3-bromoanilino)-6-nitroquinazoline | HCID 5328217 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 7-Amino-4-(3-bromoanilino)-6-nitroquinazoline | HCID 5328214 | 87.1% |
반응 단계
A solution of 7-acetamido-4-(3-bromoanilino)-6-nitroquinazoline (1.50 g, 3.73 mmol) and KOH (2 g) in MeOH (190 mL) and H2O (10 mL) is heated under reflux for 30 min, and the solvent volume is reduced to give 7-amino-4-(3-bromoanilino)-6-nitroquinazoline (1.17 g, 87%). 1H NMR (DMSO) δ10.17 (1H, brs), 9.43 (1H, s), 8.43 (1H, s), 8.15 (1H,m brs), 7.86 (1H, d, J=7.1 Hz), 7.42 (2H, brs), 7.40-7.31 (2H, m), 7.12 (1H, s).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05679683 |
| 출처 데이터셋 | uspto-grants-1997_10 |
| ORD ID | ord-a914b0f35a9b4ed48a5d1bcb701c6e44 |
| 출처 메모 | uspto-grants-1997_10 |