7-Amino-5,5-dimethyl-1,3,4,5-tetrahydro-benzo[b]azepin-2-one → 7-[5-Chloro-4-(4-morpholin-4-yl-2-pyrazol-1-yl-phenylamino)-pyrimidin-2-ylamino]-5,5-dimethyl-1,3,4,5-tetrahydro-benzo[b]azepin-2-one

HRID 148960Notes

Reaction equation

HRID 148960 reaction equation
[Cl:1][c:2]1[n:3][cH:4][c:5]([Cl:26])[c:6]([NH:8][c:9]2[c:10](-[n:21]3[n:22][cH:23][cH:24][cH:25]3)[cH:11][c:12]([N:15]3[CH2:16][CH2:17][O:18][CH2:19][CH2:20]3)[cH:13][cH:14]2)[n:7]1.[NH2:27][c:28]1[cH:29][c:30]2[c:31]([cH:40][cH:41]1)[NH:32][C:33](=[O:39])[CH2:34][CH2:35][C:36]2([CH3:37])[CH3:38]>>[c:2]1([NH:27][c:28]2[cH:29][c:30]3[c:31]([cH:40][cH:41]2)[NH:32][C:33](=[O:39])[CH2:34][CH2:35][C:36]3([CH3:37])[CH3:38])[n:3][cH:4][c:5]([Cl:26])[c:6]([NH:8][c:9]2[c:10](-[n:21]3[n:22][cH:23][cH:24][cH:25]3)[cH:11][c:12]([N:15]3[CH2:16][CH2:17][O:18][CH2:19][CH2:20]3)[cH:13][cH:14]2)[n:7]1

Participants

3

Reactant 2

HCID 578538307-Amino-5,5-dimethyl-1,3,4,5-tetrahydro-benzo[b]azepin-2-oneHCID 86633899(2,5-Dichloro-pyrimidin-4-yl)-(4-morpholin-4-yl-2-pyrazol-1-yl-phenyl)-amine

Product 1

HCID 668305277-[5-Chloro-4-(4-morpholin-4-yl-2-pyrazol-1-yl-phenylamino)-pyrimidin-2-ylamino]-5,5-dimethyl-1,3,4,5-tetrahydro-benzo[b]azepin-2-one

Sources & evidence

ORD record
ord-65e0d83960f04098898a55ba95cff8f5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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