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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 14897Generated: October 30, 2026

Tert-butyl 3,5-dimethylpiperazine-1-carboxylate → 4-[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-3,5-dimethyl-piperazine-1-carboxylic acid tert-butyl ester

https://huagongshe.com/reaction/14897

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTert-butyl 3,5-dimethylpiperazine-1-carboxylateHCID 22219990—
Reactant3-(2-Chloro-pyrimidin-4-yl)-benzaldehydeHCID 24901965—
Product4-[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-3,5-dimethyl-piperazine-1-carboxylic acid tert-butyl esterHCID 86603308—

Reaction Steps

Intermediate 1 was coupled with 3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester following procedure B. LC-MS showed the product had the expected M+H+ of 417.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07732444B2
Source datasetuspto-grants-2010_06
ORD IDord-0a23445d0c5a48e896afb7b481061c1e
Source noteuspto-grants-2010_06