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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 148974Generated: October 26, 2026

Methanol → 4-(9'-cyclohexyl-5'-methyl-6'-oxo-5',6',8',9'-tetrahydrospiro[cyclopropane-1,7'-pyrimido[5,4-b][1,4]diazepine]-2'-ylamino)-N-(1-ethyl-4-piperidyl)-2-fluoro-5-methoxy-benzamide

https://huagongshe.com/reaction/148974

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethanolHCID 887—
ReactantWaterHCID 962—
Reactantp-Toluenesulfonic acidHCID 6101—
Reactant4-Methyl-2-PentanolHCID 7910—
Reactant2'-chloro-9'-cyclohexyl-5'-methyl-8',9'-dihydrospiro[cyclopropane-1,7'-pyrimido[5,4-b][1,4]diazepin]-6'(5'H)-oneHCID 57969884—
Reactant4-amino-N-(1-ethyl-4-piperidyl)-2-fluoro-5-methoxy-benzamideHCID 68681795—
Product4-(9'-cyclohexyl-5'-methyl-6'-oxo-5',6',8',9'-tetrahydrospiro[cyclopropane-1,7'-pyrimido[5,4-b][1,4]diazepine]-2'-ylamino)-N-(1-ethyl-4-piperidyl)-2-fluoro-5-methoxy-benzamideHCID 25005297—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (9/10)
ORD IDord-96bcdf49c20f49759a182be2a4762048
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (9/10)