HCID 22902425, compound → HCID 22902421, compound

Participants

Reaction Steps

Benzyl 2-((hydroxy(methyl)phosphinyl)methyl)-4-phenylbutanoate (433 mg, 1.25 mmol) was dissolved in 95% ethanol (8.0 mL) and catalyst (130 mg of 10% palladium on carbon) was added. After being stirred under hydrogen (1 atm.) for 20 h at room temperature, the mixture was filtered through a 1-cm plug of Celite with additional 95% ethanol (2×10 mL). Evaporation of the filtrate gave 350 mg of a colorless oil used directly in Step C.

Provenance & Evidence