Sodium Hydroxide → HCID 70076214, compound

HRID 1489796Notes

Reaction equation

HRID 1489796 reaction equation
C[O:2][P@:3]([CH2:23][N:24]([C:39](=[O:49])[CH2:40][CH2:41][CH2:42][C:43]1[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=1)[C@H:25]([C:30]([N-:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)=[O:31])[CH2:26][CH:27]([CH3:29])[CH3:28])([C@@H:5]([NH:7][C:8](=[O:22])[C@H:9]([CH3:21])[NH:10][C:11](=[O:20])[C@@H:12]1[CH2:16][CH2:15][CH2:14][N:13]1[C:17](=[O:19])[CH3:18])[CH3:6])=[O:4].[OH-].[Na+]>CO>[C:33]1([NH:32][C:30](=[O:31])[C@H:25]([CH2:26][CH:27]([CH3:29])[CH3:28])[N:24]([CH2:23][P:3]([OH:4])([C@@H:5]([NH:7][C:8](=[O:22])[C@H:9]([CH3:21])[NH:10][C:11](=[O:20])[C@@H:12]2[CH2:16][CH2:15][CH2:14][N:13]2[C:17](=[O:19])[CH3:18])[CH3:6])=[O:2])[C:39](=[O:49])[CH2:40][CH2:41][CH2:42][C:43]2[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=2)[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178502959HCID 178502959, compound

Product 1

HCID 70076214HCID 70076214, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of [[(R,S)-Methoxy[1(R)-[N-(N-acetyl-L-prolyl-L-alanyl)-amino]-ethyl]-phosphinyl]methyl]-4-phenylbutanoyl-L-leucyl N-phenylamide (58 mg, 0.096 mmol) in methanol (0.5 mL) was treated with 2N aqueous sodium hydroxide (0.25 mL) for 4 hours at room temperature. The mixture was evaporated, dissolved in water, acidified to pH~1 with 2N hydrochloric acid, and extracted 4 times with ethyl acetate. The combined organic extracts were washed with saturated brine solution, dried (magnesium sulfate), and evaporated.

Workup

  1. customThe mixture was evaporated
  2. dissolutiondissolved in water
  3. extractionextracted 4 times with ethyl acetate
  4. washThe combined organic extracts were washed with saturated brine solution
  5. dry with materialdried (magnesium sulfate)
  6. customevaporated

Sources & evidence

ORD record
ord-2f718a9047bd4e1da53107e64eb0b76e
Source dataset
uspto-grants-1997_10
Patent number
US05679700

Reaction notes

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