1-Bromo-7-fluoroheptane → 4-(4-(7-Fluoroheptyl)-4-silacyclohexyl)-1,2-difluorobenzene

Participants

Role	Name	HCID	Charge
Reactant	1-Bromo-7-fluoroheptane	HCID 3028506	—
Reactant	Magnesium	HCID 5462224	—
Reactant	1-Chloro-4-(3,4-difluorophenyl)-1-silacyclohexane	HCID 131719128	—
Solvent	Tetrahydrofuran	HCID 8028	—
Product	4-(4-(7-Fluoroheptyl)-4-silacyclohexyl)-1,2-difluorobenzene	HCID 54738299	93%

Reaction Steps

3.0 g (20 mmol) of 1-bromo-7-fluoroheptane was dripped into a mixture of 0.5 g of magnesium (21 mmol) and 50 ml of THF to obtain Grignard's reagent. This reagent was then dripped into a 50 ml THF solution of 4.9 g (20 mmol) of 4-(4-chloro-4-silacyclohexyl) -1.2-difluorobenzene to obtain 4-(4-(7-fluoroheptyl)-4-silacyclohexyl)-1,2-difluorobenzene.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05679746
Source dataset	uspto-grants-1997_10
ORD ID	ord-c4a58bd1352b41e39f025affb0797ed7
Source note	uspto-grants-1997_10