4-(4,4-Difluorobutyl)cyclohexylbromide → HCID 178506043, compound

HRID 1489809Notes

Reaction equation

HRID 1489809 reaction equation
[F:1][CH:2]([F:13])[CH2:3][CH2:4][CH2:5][CH:6]1[CH2:11][CH2:10][CH:9](Br)[CH2:8][CH2:7]1.Cl[SiH:15]1[CH2:20][CH2:19][CH:18]([C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=2)[CH2:17][CH2:16]1.Cl[SiH]1CCC(C2C=CC(F)=C(F)C=2)CC1>>[F:1][CH:2]([F:13])[CH2:3][CH2:4][CH2:5][C@H:6]1[CH2:11][CH2:10][C@H:9]([Si@H:15]2[CH2:20][CH2:19][C@H:18]([C:21]3[CH:22]=[CH:23][C:24]([Cl:27])=[CH:25][CH:26]=3)[CH2:17][CH2:16]2)[CH2:8][CH2:7]1

Participants

4

Reactant 3

HCID 229026154-(4,4-Difluorobutyl)cyclohexylbromideHCID 1233243194-(4-Chloro-4-silacyclohexyl)-1-chlorobenzeneHCID 1317191281-Chloro-4-(3,4-difluorophenyl)-1-silacyclohexane

Product 1

HCID 178506043HCID 178506043, compound

Procedure

The above compound was obtained in the same manner as Example 6, using 4-(4,4-difluorobutyl)cyclohexylbromide and 4-(4-chloro-4-silacyclohexyl)-1-chlorobenzene instead of 4-(4-fluorobutyl)cyclohexybromide and 4-(4-chloro-4-silacyclohexyl)-1,2-difluorobenzene, respectively.

Workup

  1. customThe above compound was obtained in the same manner as Example 6

Sources & evidence

ORD record
ord-b4dfbf2042684e128e932e7b1c862a46
Source dataset
uspto-grants-1997_10
Patent number
US05679746

Reaction notes

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