HCID 123545774, compound → HCID 178448135, compound

Participants

Reaction Steps

4.7 g (20 mmol) of 4-(4-fluorobutyl) cyclohexyl bromide was dripped into a mixture of 0.5 g of magnesium (21 mmol) and 50 ml of THF to obtain Grignard's reagent. This solution was then added to a mixture of 3.0 g (22 mmol) of zinc chloride and 10 ml of TMF to obtain the organic zinc reagent. This reagent was then dripped into a 50 ml THF solution of 4.7 g (20 mmol) of 4-(4-chloro-4-silacyclohexyl) benzonitrile to obtain 4-(4-(trans-4-n-propylcyclohexyl)-4-silacyclohexyl) benzonitrile. This product was a mixture of trans isomers and cis isomers with regard to the silacyclohexane ring. They were separated by means of chromatography to obtain 5.9 g of the trans isomers (yield 83%).

Provenance & Evidence