反应详情

3.00 g (10.0 mmol) of 5-hydroxy-2-(4-octyloxyphenyl)pyrimidin, 1.56 g (10.0 mmol) of 3-cyclohexylpropionic acid, 2.06 g (10.0 mmol) of N,N-dicyclohexylcarbodiimide and 0.1 g of 4-N,N-dimethylaminopyridine in 80 ml of dichloromethane are stirred at room temperature for 18 hours. Insoluble constituents are then filtered off, the mixture is evaporated, and the residue is purified by chromatography (silica gel/dichloromethane) and recrystallization from hexane, giving 2.52 g of 2-(4-octyloxyphenyl)pyrimidin-5-yl 3-cyclohexylpropionate. ##STR12##

1. filtrationInsoluble constituents are then filtered off
2. customthe mixture is evaporated
3. customthe residue is purified by chromatography (silica gel/dichloromethane) and recrystallization from hexane