Acetic Acid → HCID 14346270, compound

Participants

Reaction Steps

12.0 g (12.7 mmol) of 2-(4-hydroxybenzyl)-1,4,7,10-tetra-tosyl-1,4,7,10-tetraazacyclodecane is heated in 50 ml of glacial acetic acid with 33% of hydrogen bromide for four hours to 100° C. It is poured into 300 ml of diethyl ether, suctioned off and resuspended twice in 300 ml of diethyl ether each. All operations are performed under nitrogen protective atmosphere. After drying in a vacuum, 5.16 g (78% of theory) is present of colorless crystals, which melt with decomposition at 115°-117° C.

Provenance & Evidence