1-Butanol → Quinoline

Participants

Reaction Steps

A mixture of 0.80 g of 3,4-dihydroxy-3-cyclobutene-1,2-dione, 5.99 g of 2,3,3-trimethyl1-propyl-3H-benzoindolium p-toluenesulfonate obtained in Reference Example 1, 1.64 g of quinoline, 30 ml of butanol and 30 ml of benzene was stirred under reflux for 11 hours. After the reaction solution was concentrated, 30 ml of ethanol was added to the residue, followed by heating for 30 minutes. After cooling, the crystals were filtered off and dried in vacuo to give 2.07 g of Compound 2.

Provenance & Evidence