Sulfur Dioxide → HCID 21480489, compound

Participants

Reaction Steps

A solution of the product of Step G (1 g, 3.1 mmol) in THF (20 mL) at -78° C. was treated with 2.5M n-butyllithium (1.86 g, 4.65 mmol), sulfur dioxide, and hydroxylamine-O-sulfonic acid (1.05 g, 9.3 mmol) as described in Example 1, Step F to provide, after column chromatography (silica, methanol/dichloromethane, 1:9), the desired compound (70 mg, 6%) as an off-white solid: mp 170° C. dec.

Provenance & Evidence