Water → HCID 67709581, compound

HRID 1490087Notes

Reaction equation

HRID 1490087 reaction equation
[NH2:1][N:2]=[CH:3][C:4]1[CH:9]=[CH:8][C:7]([CH:10]=[CH:11][C:12]([NH:14][CH2:15][CH2:16][CH2:17][N:18]2[CH2:22][C:21](=[O:23])[N:20]([CH:24]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[C:25]([O:27]C)=[O:26])[C:19]2=[O:35])=[O:13])=[CH:6][CH:5]=1.[OH-:36].[Na+].O>CO>[C:25]([OH:27])(=[O:26])[CH3:24].[NH2:1][N:2]=[CH:3][C:4]1[CH:9]=[CH:8][C:7]([CH:10]=[CH:11][C:12]([NH:14][CH2:15][CH2:16][CH2:17][N:18]([CH2:22][C:21]([OH:36])=[O:23])[C:19]([NH:20][CH:24]([C:25]([OH:27])=[O:26])[C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)=[O:35])=[O:13])=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 86751447HCID 86751447, compound

Product 1

HCID 67709581HCID 67709581, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

78 mg (0.165 mmol) of methyl (3-(3-(3-(4-(aminoiminomethyl)phenyl)acryloylamino)propyl)-2,5-dioxoimidazolidin-1-yl)phenylacetate are stirred at room temperature for 20 h together with 2 ml of 1N sodium hydroxide solution, 5 ml of water and 5 ml of methanol. Following concentration, the residue is, for purification, chromatographed on Sephadex LH20 using an homogeneous mixture of butanol/glacial acetic acid/water.

Workup

  1. concentrationconcentration
  2. customthe residue is, for purification
  3. customchromatographed on Sephadex
  4. additionan homogeneous mixture of butanol/glacial acetic acid/water

Sources & evidence

ORD record
ord-2d06810e4b34437c973f3cb0cbc2513c
Source dataset
uspto-grants-1997_10
Patent number
US05681838

Reaction notes

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