HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Fmoc-N-(2-Boc-aminoethyl)-Gly-OH
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | N-(9-Fluorenylmethoxycarbonyloxy)succinimide | HCID 134122 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | ({2-[(Tert-butoxycarbonyl)amino]ethyl}amino)acetic acid | HCID 9834393 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Fmoc-N-(2-Boc-aminoethyl)-Gly-OH | HCID 2756167 | — |
Reaction Steps
10.9 g (50 mmol) of N-(2-tert-butoxycarbonylaminoethyl)aminoacetic acid are stirred together with 50 ml of water, 11.3 g (135 mmol) of sodium hydrogen carbonate and 50 ml of tetrahydrofuran. Subsequently, 24.3 g (72 mmol) of N-(9-fluorenylmethoxycarbonyloxy)succinimide are added. The mixture is stirred at room tmeperature for 20 h and the salt removed by filtration; the filtrate is acidified and the phases separated, and the organic phase is then concentrated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05681838 |
| Source dataset | uspto-grants-1997_10 |
| ORD ID | ord-f821c4dbe7f343db800fbe533e4fffad |
| Source note | uspto-grants-1997_10 |