Methanol → HCID 21480541, compound

HRID 1490090Notes

Reaction equation

HRID 1490090 reaction equation
S(Cl)([Cl:3])=O.Cl.[NH2:6][CH2:7][CH2:8][N:9]([CH2:27][C:28]([OH:30])=[O:29])[C:10]([O:12][CH2:13][CH:14]1[C:26]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[C:20]2[C:15]1=[CH:16][CH:17]=[CH:18][CH:19]=2)=[O:11].[CH3:31]O>>[ClH:3].[NH2:6][CH2:7][CH2:8][N:9]([CH2:27][C:28]([O:30][CH3:31])=[O:29])[C:10]([O:12][CH2:13][CH:14]1[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:20]=2[C:21]2[C:26]1=[CH:25][CH:24]=[CH:23][CH:22]=2)=[O:11]

Participants

4

Reactant 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 70214570HCID 70214570, compound

Product 1

HCID 21480541HCID 21480541, compound

Conditions

Temperature
0 °C

Procedure

2.15 ml of thionyl chloride are added dropwise, at 0° C., to 75 ml of anhydrous methanol. Subsequently, 7.5 g (20 mmol) of N-(2-aminoethyl)-N-(9-fluorenylmethoxycarbonyl)aminoacetic acid hydrochloride are added in portions. The mixture is stirred at 0° C. for one hour, allowed to warm to room temperature, and then stirred further overnight. The reaction solution is concentrated and the precipitate is filtered off with suction and dried.

Workup

  1. temperatureto warm to room temperature
  2. stirringstirred further overnight
  3. concentrationThe reaction solution is concentrated
  4. filtrationthe precipitate is filtered off with suction
  5. customdried

Sources & evidence

ORD record
ord-c8ade7d831e5490c8b72e2e05716bb0f
Source dataset
uspto-grants-1997_10
Patent number
US05681838

Reaction notes

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