Sodium Hydroxide → HCID 178512527, compound

HRID 1490096Notes

Reaction equation

HRID 1490096 reaction equation
Cl.[NH:2]([C:6]1[CH:35]=[CH:34][C:9]([C:10]([NH:12][CH2:13][CH2:14][CH2:15][N:16]2[CH2:20][C:19](=[O:21])[N:18]([CH:22]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[C:23]([O:25]C)=[O:24])[C:17]2=[O:33])=[O:11])=[CH:8][CH:7]=1)[C:3]([NH2:5])=[NH:4].[OH-:36].[Na+]>CO.O>[C:23]([CH:22]([C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1)[NH:18][C:17](=[O:33])[N:16]([CH2:20][C:19]([OH:36])=[O:21])[CH2:15][CH2:14][CH2:13][NH:12][C:10](=[O:11])[C:9]1[CH:8]=[CH:7][C:6]([NH:2][C:3]([NH2:5])=[NH:4])=[CH:35][CH:34]=1)([OH:25])=[O:24]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 178499406HCID 178499406, compound

Product 1

HCID 178512527HCID 178512527, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

380 mg (0.76 mg) of methyl (3-(3-(4-guanidinobenzoylamino)propyl)-2,5-dioxoimidazolidin-1-yl)phenylacetate hydrochloride are dissolved in 10 ml of methanol and 10 ml of water, and 2.28 ml of 1N sodium hydroxide solution are then added. The mixture is stirred at room temperature overnight, concentrated and chromatographed, for purification, on Sephadex LH20 using an homogeneous mixture of butanol/glacial acetic acid/water.

Workup

  1. concentrationconcentrated
  2. customchromatographed, for purification, on Sephadex
  3. additionan homogeneous mixture of butanol/glacial acetic acid/water

Sources & evidence

ORD record
ord-485126da3ed24495a453f1a25e4c4847
Source dataset
uspto-grants-1997_10
Patent number
US05681838

Reaction notes

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