HCID 178481571, compound → HCID 178481569, compound

Participants

Reaction Steps

The title compound was prepared from Intermediate 3 and 3-[(tetrazol-5-yl)aminomethyl]aniline using a similar method to that described for Example 4, except that anhydrous acetonitrile was used instead of tetrahydrofuran; the crude product was purified by flash chromatography (silica gel, dichloromethane-methanol, 95:5 to 90:10) and recrystallized from a mixture of methanol and ethyl acetate; mp 175°-178° C.; [α]D24 +17.4° (c=0.50, dimethylformamide); the spectroscopic properties of this material (1 H-NMR and MS spectra) were identical to those described for its racemate (Example 1).

Provenance & Evidence