Hydrochloric Acid → HCID 21480479, compound

Participants

Reaction Steps

A mixture of 2-aminobenzophenone (20 g), tert-butyl alcohol (100 ml) and 10M ethanolic hydrogen chloride (10 ml) was heated in a steel bomb at 120° C. for 20 minutes. After being cooled to room temperature, solvents were removed under vacuum and the residue was purified by flash chromatography (silica gel, hexane-toluene, 30:70) to give the title compound (5.62 g) as an oil, δH (360 MHz, CDCl3) 8.95 (1H, s), 7.61-7.28 (7H, m), 7.01 (1H, d, J=8.6 Hz), 6.48 (1H, t, J=7.4 Hz), 1.49 (9H, s); m/z (CI) 253 (M-).

Provenance & Evidence