Trifluoroacetic acid → HCID 18967729, compound

Participants

Reaction Conditions

Reaction Steps

3,4,5,6,7,8-Hexahydro-6-((4-methoxyphenyl)methyl)quinolin-2[1H]-one (1.5 g) (prepared according to Example 9) was dissolved in dichloromethane (50 ml) and cooled to 0° C. Triethylsilane (0.9 ml and trifluoroacetic acid (5 ml) were added and the mixture was stirred for 2 hours. The reaction mixture was then evaporated under reduced pressure, crystallised by addition of ether and recrystallised from acetonitrile to give the title compound (0.7 g), mp 194°-196° C.

Provenance & Evidence