4-(4-Chlorophenyl)-4-hydroxypiperidine → 1-(2-Chloro-9,10-dihydro-9,10-methanoanthracen-9-ylmethyl)-4-(4-chlorophenyl)piperidin-4-ol

Participants

Role	Name	HCID	Charge
Reactant	4-(4-Chlorophenyl)-4-hydroxypiperidine	HCID 38282	—
Reactant	2-Chloro-9-formyl-9,10-dihydro-9,10-methanoanthracene	HCID 19698639	—
Product	1-(2-Chloro-9,10-dihydro-9,10-methanoanthracen-9-ylmethyl)-4-(4-chlorophenyl)piperidin-4-ol	HCID 21480580	29%

Reaction Steps

Using a procedure similar to that described in example 21 except starting with 2-chloro-9-formyl-9,10-dihydro-9,10-methanoanthracene (described in example 1i) and 4-(4-chlorophenyl)-4-hydroxypiperidine, the title compound hydrochloride salt was obtained in 29% yield as a white powder, mp 261°-263° C. elemental

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05681840
Source dataset	uspto-grants-1997_10
ORD ID	ord-3dee6bd24a9949389e5707e3bdf66552
Source note	uspto-grants-1997_10