HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Methoxy-N-methylbenzamide → 2-Phenyl-1H-pyrrolo[3,2-C]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Methoxy-N-methylbenzamide | HCID 569575 | — |
| Reactant | tert-butyl N-(3-methylpyridin-4-yl)carbamate | HCID 15273533 | — |
| Reactant | HCID 178418306 | HCID 178418306 | — |
| Product | 2-Phenyl-1H-pyrrolo[3,2-C]pyridine | HCID 15210862 | — |
Reaction Steps
4-tert-Butoxycarbonylamino-3-methylpyridine (Example 11a, 1.0 g, 4.8 mmol) was dilithiated with t-butyllithium and treated with N-methoxy-N-methylbenzamide (0.95 g, 5.76 mmol) as described previously. The crude product was purified by trituration with ethyl acetate to afford the title compound as a pale beige solid; yield: 0.59 g (63%); mp 276°-278°C.[Lit. mp 282°-283° C.].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05681959 |
| Source dataset | uspto-grants-1997_10 |
| ORD ID | ord-ba3c977682f5489481c2938aa8bd8000 |
| Source note | uspto-grants-1997_10 |