Methyl triflate → HCID 86751471, compound

Participants

Reaction Steps

To a suspension of 11-chlorobenzofuro[3, 2-b]quinoline from Example 55 (0.4 g, 1.6. mol) in anhydrous toluene (15 mL) was added methyltriflate (0.52 g, 0.36 mL, 200 mol %). The reaction mixture was stirred for 20 h at rt, diluted with ether, and stirred for 1 h. The solid product was filtered to afford after drying, 0.41 g (62%) of the title compound, mp 221°-223° C. (became "wet" at 200°-202° C.); 1H NMR (DMSO-d6) δ 8.90 (q, 2H, J=8), 8.73 (dd, 1H, J=1.2, J=8), 8.40-8.36 (m, 1H), 8.24-8.14 (m, 3H), 7.83 (m, 1H); 13C NMR (DMSO-d6) δ 159.53, 145.04, 142.89, 137.44, 136.69, 134.57, 130.32, 129.93, 127.05, 126.02, 125.43, 125.38, 124.73, 119.23, 116.62, 113.80, 106.93, 40.00; MS (FAB, m/z) 268 (M+).

Provenance & Evidence