HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → 4-chloro-N-phenethylbenzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | Phenethylamine | HCID 1001 | — |
| Reactant | 4-Chlorobenzenesulfonyl chloride | HCID 7398 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Catalyst | Tetrabutylammonium Bromide | HCID 74236 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-chloro-N-phenethylbenzenesulfonamide | HCID 722861 | — |
Reaction Steps
To a mixture of 150 ml of ethylene chloride and 150 ml of water are added 30.3 g of 2-phenylethylamine, 12 g of sodium hydroxide and 0.5 g of tetrabutylammonium bromide. 65.5 g of 4-chlorobenzenesulphonic acid chloride are added to the mixture in batches with stirring. After 30 minutes the organic phase is separated off, evaporated down and the residue is recrystallised from toluene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05681961 |
| Source dataset | uspto-grants-1997_10 |
| ORD ID | ord-67782c2be1ce455088bebafa349fdd7c |
| Source note | uspto-grants-1997_10 |