Methyl 6-(2-(4-bromobenzenesulphonylamino)indan-5-yl)-6-(3-pyridyl)hex-5-enoate → 6-(2-(4-Bromobenzenesulphonylamino)indan-5-yl)-6-(3-pyridyl)hex-5-enoic acid

HRID 1490371Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1490371
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH:12]2[CH2:20][C:19]3[C:14](=[CH:15][CH:16]=[C:17]([C:21]([C:30]4[CH:31]=[N:32][CH:33]=[CH:34][CH:35]=4)=[CH:22][CH2:23][CH2:24][CH2:25][C:26]([O:28]C)=[O:27])[CH:18]=3)[CH2:13]2)(=[O:10])=[O:9])=[CH:4][CH:3]=1>C(O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH:12]2[CH2:20][C:19]3[C:14](=[CH:15][CH:16]=[C:17]([C:21]([C:30]4[CH:31]=[N:32][CH:33]=[CH:34][CH:35]=4)=[CH:22][CH2:23][CH2:24][CH2:25][C:26]([OH:28])=[O:27])[CH:18]=3)[CH2:13]2)(=[O:10])=[O:9])=[CH:4][CH:3]=1

Komponenten

3

Edukt 1

HCID 53803137Methyl 6-(2-(4-bromobenzenesulphonylamino)indan-5-yl)-6-(3-pyridyl)hex-5-enoate

Produkt 1

HCID 544684286-(2-(4-Bromobenzenesulphonylamino)indan-5-yl)-6-(3-pyridyl)hex-5-enoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

3.7 g of methyl 6-(2-(4-bromobenzenesulphonylamino)-indan-5-yl)-6-(3-pyridyl)hex-5-enoate are refluxed for 15 minutes in 30 ml of ethanol and with 1N of 15N sodium hydroxide solution. After cooling the solution is rotary evaporated and the residue is taken up in water and washed with 30 ml of methylene chloride. Then the aqueous phase is adjusted to pH 4 using hydrochloric acid. The precipitate formed is washed and dried.

Aufarbeitung

  1. temperatureAfter cooling the solution
  2. customis rotary evaporated
  3. washwashed with 30 ml of methylene chloride
  4. customThe precipitate formed
  5. washis washed
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-e516d9e3afc94c1c8557bd25da87a650
Quelldatensatz
uspto-grants-1997_10
Patentnummer
US05681961

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