HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1490500Generated: October 31, 2026
1,2,3,4-Tetrahydro-1-methylquinoline → HCID 69620572, compound
https://huagongshe.com/reaction/1490500
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,2,3,4-Tetrahydro-1-methylquinoline | HCID 68109 | — |
| Reagent | Pinacol | HCID 6425 | — |
| Reagent | Triethylamine | HCID 8471 | — |
| Reagent | Catecholborane | HCID 67506 | — |
| Catalyst | Tris(pentafluorophenyl)borane | HCID 582056 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 69620572 | HCID 69620572 | 83% |
Reaction Steps
Prepared from 1-methyl-1,2,3,4-tetrahydroquinoline (1k, 29.4 mg, 0.200 mmol, 1.00 equiv) and catBH (36.0 mg, 0.300 mmol, 1.50 equiv) according to GP 1. The title compound was purified by flash column chromatography using cyclohexane/EtOAc/Et3N (30/1/1) as eluent to afford 3k (45.3 mg, 83%) as a white solid.
Provenance & Evidence
| DOI | 10.1002/anie.201611536 |
|---|
| Source dataset | Borylation dataset from Roche |
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| ORD ID | ord-d3ba5717f432449fad3bb49fdeacca0e |
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| Source note | Borylation dataset from Roche |
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