HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1490568Generated: October 31, 2026
Benzene, 1-chloro-4-(1,1-dimethylethyl)- → HCID 129946666, compound
https://huagongshe.com/reaction/1490568
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzene, 1-chloro-4-(1,1-dimethylethyl)- | HCID 77594 | — |
| Reagent | Bis(pinacolato)diborane | HCID 2733548 | — |
| Reagent | 3-pyridin-2-yl-2-(3-pyridin-2-yl-1H-1,3,2-benzodiazaborol-2-yl)-1H-1,3,2-benzodiazaborole | HCID 122380799 | — |
| Catalyst | Bis(1,5-cyclooctadiene)dimethoxydiiridium | HCID 76001521 | — |
| Solvent | Cyclopentyl methyl ether | HCID 138539 | — |
| Product | HCID 129946666 | HCID 129946666 | 80% |
Reaction Steps
The general procedure A was followed using 1-(tert-butyl)-4-chlorobenzene (79.1 ul, 0.5 mmol) and B2pin2 (126.9 mg, 0.5 mmol, 1.0 eq.) as starting material. The resulting mixture was allowed to stir 16 hours at 100 oC. 5aa was obtained as white solid (118.0 mg, 80%) after purification by silica gel flash chromatography (EtOAc/PE=1:50 v/v). m.p.: 73-75 oC.
Provenance & Evidence
| DOI | 10.1021/jacs.5b05252 |
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| Source dataset | Borylation dataset from Roche |
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| ORD ID | ord-db591dda52a34d67a62a70de910a941f |
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| Source note | Borylation dataset from Roche |
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