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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1490712Generated: October 25, 2026

Benzoic acid, 2-fluoro-, ethyl ester → Ethyl 2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

https://huagongshe.com/reaction/1490712

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzoic acid, 2-fluoro-, ethyl esterHCID 67953—
ReagentBis(pinacolato)diboraneHCID 2733548—
ReagentPotassium tert-butoxideHCID 86639980—
Reagent8-([2,2'-bipyridin]-5-yl)quinolin-2(1H)-oneHCID 164681385—
CatalystBis(1,5-cyclooctadiene)dimethoxydiiridiumHCID 76001521—
SolventTetrahydrofuranHCID 8028—
ProductEthyl 2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoateHCID 2203258291%

Reaction Conditions

Temperature80 °C

Provenance & Evidence

DOI10.1021/jacs.7b04490
Source datasetBorylation dataset from Roche
ORD IDord-7d848437d111404f9b93701a5deb800f
Source noteBorylation dataset from Roche