HCID 102470805, compound → HCID 178431072, compound

Participants

Reaction Conditions

Reaction Steps

Following general procedure F using 4d (86 mg, 0.25 mmol), B2pin2 (127 mg, 0.50 mmol), [Ir(COD)OMe]2 (2.5 mg, 0.00375 mmol) and 1a (3.8 mg, 0.0075 mmol) in THF (1.25 mL). Stirred in vial at 50 °C for 20 hours. Analysis of crude 1 H NMR using internal standard 1,2‐dimethoxyethane showed 5.7:1 meta:para borylation in 85% yield (12% starting material remaining). The crude product was purified by silica gel chromatography (15% EtOAc in Petroleum Ether 40‐60 o C) gave the title compound (as a 5.4:1 mixture of meta:para ratio, as determined by 1 H NMR) as a yellowish oil (79 mg, 0.17 mmol, 68%).

Provenance & Evidence