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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1490847Generated: October 30, 2026

2-Methyl-2,3-dihydro-1H-isoindol-1-one → 2-Methyl-6-(4,4,5,5-tetraMethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-isoindol-1-one

https://huagongshe.com/reaction/1490847

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methyl-2,3-dihydro-1H-isoindol-1-oneHCID 220657—
ReagentBis(pinacolato)diboraneHCID 2733548—
ReagentHCID 91820779HCID 91820779—
CatalystBis(1,5-cyclooctadiene)dimethoxydiiridiumHCID 76001521—
SolventP-XyleneHCID 7809—
Product2-Methyl-6-(4,4,5,5-tetraMethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-isoindol-1-oneHCID 4685641639%
Product2-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-oneHCID 5769122412%

Reaction Conditions

Temperature35 °C

Provenance & Evidence

DOI10.1038/nchem.2322
Source datasetBorylation dataset from Roche
ORD IDord-2d49cc7858d3490f9864f2f68d247fdc
Source noteBorylation dataset from Roche